Image courtesy of Artist Mike Halerz in collaboration with scientists Ki Sueng Choi, Christopher Rozell, and Helen Mayberg

Depression is one of the leading causes of disability around the world, with almost 30% of cases being treatment resistant with no approved therapy providing relief. Increasingly, the brain networks implicated in treatment resistant depression is being identified and deep brain stimulation is used as a successful therapy. This image illustrates our recent work advancing this experimental therapy, where new recording technology is paired with novel AI methods to show for the first time how brain activity changes with recovery, providing valuable objective data to optimize patient care. The image shows the 3D white matter structure of a patient in our study as mapped diffusion tensor imaging. The network targeted by the stimulator is highlighted, and the streaming data informing clinical care is illustrated.